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Nucleic Acids

Easychemistry

A student writes that a nucleoside and a nucleotide differ by only one component group. Which statement correctly distinguishes a nucleotide from the corresponding nucleoside?

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About This Question

Subject
chemistry
Chapter
biomolecules
Topic
nucleic acids
Difficulty
Easy
Year
2025
Tags
nucleosidenucleotidephosphate esterN-glycosidic bondnucleic acid structure

Solution

Correct Answer:

A nucleotide additionally carries a phosphate group esterified to the sugar

Nucleic acids are polymers whose repeating units are built in two stages, and distinguishing the intermediates clarifies the polymer's architecture. A nucleoside is formed when a nitrogenous base (a purine or pyrimidine) attaches through an N-glycosidic bond to the C1 carbon of a pentose sugar, either ribose or deoxyribose. A nucleotide is produced when a phosphate group is then esterified, usually at the C5 hydroxyl of that same sugar. Therefore the single component that a nucleotide possesses beyond a nucleoside is the phosphate unit, making the first option correct. The claim that a nucleotide lacks the base is wrong, since both retain the base. The option tying nucleotide exclusively to ribose and nucleoside to deoxyribose is false because either sugar can appear in both. The suggestion of two bases on one sugar describes no standard unit. This matches the NCERT description of nucleosides and nucleotides in the Biomolecules chapter. As a consistency check, linking nucleotides through phosphodiester bonds between the C3 and C5 positions of adjacent sugars builds the nucleic acid backbone, which requires exactly the phosphate group that defines a nucleotide.

This easy difficulty chemistry question is from the chapter biomolecules, covering the topic of nucleic acids. It appeared in the 2025 exam.

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