Fertilization

Question

Acrosomal reaction facilitates penetration of which layer surrounding the oocyte?

RankGuru · Accepted Answer

1. **Acrosome**: A cap-like structure on the sperm head filled with enzymes (like hyaluronidase and acrosin).
2. **Mechanism**: When sperm makes contact with the ovum, the acrosomal reaction is triggered.
3. **Layers to Penetrate**: The sperm must first pass the outer *corona radiata*, but the acrosomal enzymes specifically facilitate the penetration of the **Zona pellucida** (the non-cellular glycoprotein layer).
4. **Fusion**: Once through the zona pellucida, the sperm membrane fuses with the plasma membrane of the ovum, triggering the block to polyspermy.

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Fertilization

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