denaturation

Question

Protein denaturation primarily disrupts:

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1. **Folded State**: Natural proteins are in a specific 3D shape called the 'native conformation'.
2. **Denaturation**: A process where a protein loses its biological activity due to physical or chemical changes (high temp, pH change).
3. **What breaks**: It disrupts the relatively weak **non-covalent interactions** (Hydrogen bonds, hydrophobic interactions, salt bridges) and sometimes disulfide bonds.
4. **What remains**: The **primary structure** (linear sequence of amino acids held by covalent peptide bonds) is usually unaffected.
5. **Result**: The protein becomes 'uncoiled' and loses its functional shape.

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More denaturation Practice Questions

Denaturation of proteins involves: