transcription

Question

In prokaryotes, promoter consensus -10 region (Pribnow box) is rich in which bases?

RankGuru · Accepted Answer

1. **Promoter**: A DNA sequence where RNA polymerase binds to initiate transcription.
2. **Pribnow Box**: In bacteria ($prokaryotes$), there is a conserved sequence centered around -10 nucleotides from the start site.
3. **Sequence**: The consensus sequence is **TATAAT**.
4. **Base Composition**: This region is **AT-rich**. Because A-T base pairs are held by only two hydrogen bonds (compared to three in G-C), it is energetically easier for the cell to 'melt' the DNA strands here to initiate transcription.

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More transcription Practice Questions

Which factor is required for the initiation of transcription in Prokaryotes?