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Mediumbiology

In prokaryotes, promoter consensus -10 region (Pribnow box) is rich in which bases?

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About This Question

Subject
biology
Chapter
genetics and evolution
Topic
transcription
Difficulty
Medium
Year
2025
Tags
TranscriptionPromoter

Solution

Correct Answer:

AT

  1. Promoter: A DNA sequence where RNA polymerase binds to initiate transcription.
  2. Pribnow Box: In bacteria (), there is a conserved sequence centered around -10 nucleotides from the start site.
  3. Sequence: The consensus sequence is TATAAT.
  4. Base Composition: This region is AT-rich. Because A-T base pairs are held by only two hydrogen bonds (compared to three in G-C), it is energetically easier for the cell to 'melt' the DNA strands here to initiate transcription.

This medium difficulty biology question is from the chapter genetics and evolution, covering the topic of transcription. It appeared in the 2025 exam.

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