hoffmann bromamide degradation

Question

Hoffmann bromamide reaction converts:

RankGuru · Accepted Answer

The **Hoffmann Bromamide Degradation** is used to prepare primary amines from amides.
- Reaction: $R-CONH_2 + Br_2 + 4NaOH 	o R-NH_2 + Na_2CO_3 + 2NaBr + 2H_2O$
- The reaction involves the **migration** of an alkyl/aryl group from the carbonyl carbon to the nitrogen atom.
- The carbonyl carbon is lost as carbonate ion, resulting in an amine that has **one less carbon atom** than the starting amide.
- Intermediate: An **alkyl isocyanate ($R-N=C=O$)** is formed during the mechanism.

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hoffmann bromamide degradation

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