enzyme specificity

Question

Lock-and-key model emphasizes enzyme specificity stemming from:

RankGuru · Accepted Answer

1. **Lock-and-Key Theory**: Proposed by Emil Fischer.
2. **Concept**: The enzyme (lock) has a specific, fixed 3D shape at its **active site**.
3. **Substrate (Key)**: Only a substrate with the exact **complementary shape** and charge distribution can fit into the active site.
4. **Consequence**: This explains why enzymes are highly specific for their substrates.
5. **Comparison**: The 'Induced Fit' model is slightly different, suggesting that the active site is flexible and molds around the substrate after binding.

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enzyme specificity

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