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Enzyme Specificity

Mediumchemistry

Lock-and-key model emphasizes enzyme specificity stemming from:

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About This Question

Subject
chemistry
Chapter
biomolecules
Topic
enzyme specificity
Difficulty
Medium
Year
2025
Tags
enzymesspecificity

Solution

Correct Answer:

Preformed complementary active site matching substrate

  1. Lock-and-Key Theory: Proposed by Emil Fischer.
  2. Concept: The enzyme (lock) has a specific, fixed 3D shape at its active site.
  3. Substrate (Key): Only a substrate with the exact complementary shape and charge distribution can fit into the active site.
  4. Consequence: This explains why enzymes are highly specific for their substrates.
  5. Comparison: The 'Induced Fit' model is slightly different, suggesting that the active site is flexible and molds around the substrate after binding.

This medium difficulty chemistry question is from the chapter biomolecules, covering the topic of enzyme specificity. It appeared in the 2025 exam.

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