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Digestion: Absorption

Hardbiology

Vitamin B12 absorption in ileum requires which glycoprotein?

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About This Question

Subject
biology
Chapter
human physiology
Topic
digestion: absorption
Difficulty
Hard
Year
2025
Tags
DigestionVitamins

Solution

Correct Answer:

Intrinsic factor

  1. Vitamin (Cyanocobalamin): Essential for RBC formation; absorption is complex.
  2. Stomach Phase: Parietal cells of the stomach secrete a glycoprotein called Intrinsic Factor (IF).
  3. Binding: Intrinsic factor binds to Vitamin in the small intestine, protecting it from digestion.
  4. Ileal Phase: The complex is recognized by specific receptors in the terminal ileum (the last part of the small intestine), where absorption occurs.
  5. Deficiency: Lack of Intrinsic Factor leads to Vitamin deficiency and Pernicious Anemia.

This hard difficulty biology question is from the chapter human physiology, covering the topic of digestion: absorption. It appeared in the 2025 exam.

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