cancer biology

Question

Oncogenes arise most commonly via mutation of which normal genes?

RankGuru · Accepted Answer

1. **Normal Function**: **Proto-oncogenes** are regular genes that promote cell growth and division in a controlled manner.
2. **Transformation**: When these genes undergo 'gain-of-function' mutations (due to carcinogens, viruses, or radiation), they become hyperactive.
3. **Oncogones**: The mutated, over-active versions are called **oncogenes**, which drive uncontrolled cell proliferation leading to cancer.
4. **Tumor Suppressor Genes**: These are 'brakes' that normally inhibit cell division. Their **loss-of-function** mutation (inactivation) also leads to cancer, but they are not the source of oncogenes themselves.

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cancer biology

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