Cancer Biology
Oncogenes arise most commonly via mutation of which normal genes?
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About This Question
- Subject
- biology
- Chapter
- biology and human welfare
- Topic
- cancer biology
- Difficulty
- Hard
- Year
- 2025
Solution
Correct Answer:
Proto-oncogenes
- Normal Function: Proto-oncogenes are regular genes that promote cell growth and division in a controlled manner.
- Transformation: When these genes undergo 'gain-of-function' mutations (due to carcinogens, viruses, or radiation), they become hyperactive.
- Oncogones: The mutated, over-active versions are called oncogenes, which drive uncontrolled cell proliferation leading to cancer.
- Tumor Suppressor Genes: These are 'brakes' that normally inhibit cell division. Their loss-of-function mutation (inactivation) also leads to cancer, but they are not the source of oncogenes themselves.
This hard difficulty biology question is from the chapter biology and human welfare, covering the topic of cancer biology. It appeared in the 2025 exam.
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