baeyer-villiger

Question

Baeyer–Villiger oxidation converts ketone to:

RankGuru · Accepted Answer

1. **Reactants**: A ketone is treated with a peroxy acid ($e.g.,$ $mCPBA$ or $CF_3CO_3H$).
2. **Mechanism**: The peroxy Oxygen attacks the carbonyl carbonyl, followed by the migration of one of the alkyl groups onto the Oxygen of the peroxide linkage.
3. **Functional Group Change**: This 'insertion' of an Oxygen atom converts the ketone structure into an **Ester** structure ($R-CO-R' 	o R-CO-OR'$).
4. **Predictability**: The more substituted alkyl group or the aryl group generally migrates preferentially (migratory aptitude: Tertiary > Secondary > Primary > Methyl).

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baeyer-villiger

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